Scientists Have Learned to Grow New Teeth: Regenerative Dentistry Reaches a New Level

Tooth loss has long been considered an irreversible process, with implants and prosthetics being the only restoration options. However, modern regenerative dentistry is taking a major leap forward: researchers have developed a drug capable of stimulating the growth of new teeth in adults. This discovery could completely transform dental treatment by allowing patients to naturally regenerate lost tooth tissue.

The foundation of the new technology is the inhibition of the USAG-1 protein. This protein plays a key role in regulating tooth development and suppresses new tooth buds in adulthood. Researchers found that many mammals, including humans, possess “dormant” tooth buds that could develop but remain inactive due to USAG-1’s influence. The newly created drug neutralizes this protein, activating natural regeneration mechanisms.

Animal trials produced stunning results. In mice and ferrets, new teeth began forming after administration of the drug — fully identical in structure and function to natural teeth. They grew in the correct position, had normal hardness, and developed complete root systems. Importantly, no adverse side effects were observed; the tooth growth was physiological and free of tissue abnormalities.

The next step will be human clinical trials. The first volunteers are expected to participate in the coming years. If successful, the medication may become a revolution in dentistry, helping patients restore teeth lost due to trauma, severe decay, gum disease, or congenital tooth absence.

The technology also opens new opportunities for treating age-related oral conditions. For many older adults, tooth loss severely affects nutrition, speech, and quality of life. The ability to grow new teeth without surgery could dramatically improve dental care standards for seniors.

Despite the encouraging results, researchers stress the need for further testing. Long-term safety, tooth growth rate in humans, and optimal dosing must all be evaluated. Even so, many experts already regard this discovery as one of the most anticipated breakthroughs in 21st-century dentistry.